2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-10871A
    Otenabant Hydrochloride 686347-12-6 98%
    Otenabant Hydrochloride is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.
    Otenabant Hydrochloride
  • HY-110179
    PSNCBAM-1 877202-74-9 99.48%
    PSNCBAM-1 is a selective CB1 receptor allosteric antagonist with an EC50 of 0.1 μM. PSNCBAM-1 can be used in the researches of obesity.
    PSNCBAM-1
  • HY-111180
    ML262 902502-82-3
    ML-262 is an inhibitor of hepatic lipid droplet formation (IC50=6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease.1 ML-262 does not induce cytotoxicity (up to 33 μM) or inhibit fatty acid uptake (up to 50 μM).
    ML262
  • HY-112169
    10-Formyltetrahydrofolic acid 2800-34-2 98%
    10-Formyltetrahydrofolic acid is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines.
    10-Formyltetrahydrofolic acid
  • HY-112253
    D-Fructose 1-phosphate 15978-08-2 98%
    D-Fructose 1-phosphate is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level.
    D-Fructose 1-phosphate
  • HY-112819
    Insulin levels modulator 1019254-94-4 98.38%
    Insulin levels modulator (Example 49) is an orally active insulin secretagogue. Insulin levels modulator can be used for the research of type 2 diabetes and type 2 diabetes-related disorders.
    Insulin levels modulator
  • HY-113044
    Uridine 5′-diphosphoglucose 133-89-1 98%
    Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.
    Uridine 5′-diphosphoglucose
  • HY-113143
    Galactose 1-phosphate 2255-14-3 98%
    Galactose 1-phosphate acts as a competitive substrate inhibitor of galactose-1-phosphate uridylyltransferase (GALT). Galactose 1-phosphate is a competitive inhibitor of Phosphoglucomutase, yet the rate at which this enzyme converts Galactose 1-phosphate to Galactose-6-phosphate is 400 times slower than the rate of converting Glucose-1-phosphate. Galactose 1-phosphate can be used in studies related to Saccharomyces cerevisiae infection and type I galactosemia.
    Galactose 1-phosphate
  • HY-113304
    (S)-3,4-Dihydroxybutyric acid 51267-44-8
    (S)-3,4-Dihydroxybutyric acid, a normal human urinary metabolite, is a β-oxidation metabolite of γ-hydroxybutyrate. (S)-3,4-Dihydroxybutyric acid can be used for research on succinic semialdehyde dehydrogenase deficiency.
    (S)-3,4-Dihydroxybutyric acid
  • HY-113477
    CE(20:2(6Z,9Z)) 77715-45-8 99.0%
    CE(20:2(6Z,9Z)) (Cholesteryl 11,14-eicosadienoate) is an ester product.
    CE(20:2(6Z,9Z))
  • HY-115773
    NMTCA 103659-08-1 98%
    NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid. NMTCA can be used as an indicator of endogenous nitrosation by gas chromatography-thermalenergyanalysis.
    NMTCA
  • HY-117441
    5(S)-HPEPE 143292-98-2 98%
    5(S)-HPEPE is an ester product.
    5(S)-HPEPE
  • HY-118334
    Armillaramide 111149-09-8 98.0%
    Armillaramide (Desulfated ircisulfamide) is an ester product.
    Armillaramide
  • HY-120253
    Spirotetramat 203313-25-1
    Spirotetramat (BY-108330) is an orally active Insecticide and lipid biosynthesis inhibitor. Spirotetramat regulates the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), with short-term exposure increasing their activities and long-term exposure altering their activities. Spirotetramat induces the activity and mRNA expression of carboxylesterase (CarE). Spirotetramat induces oxidative stress and lipid peroxidation in tadpoles. Spirotetramat is toxic to amphibian tadpoles and exhibits sublethal/non-lethal toxicity to amphibians. Spirotetramat causes death in immature psyllids, aphids, scale insects, mealybugs, whiteflies and thrips, and shows a high lethal rate against Cacopsylla pyri nymphs. Spirotetramat reduces the fecundity of Aphis gossypii. Spirotetramat induces tolerance in the offspring of exposed Aphis gossypii, and acts on Myzus persicae, Bemisia tabaci and Tetranychus urticae.
    Spirotetramat
  • HY-120996
    10(E)-Pentadecenoic acid 321744-58-5 ≥98.0%
    10 (E)-Pentadecenoic acid (trans-10-Pentadecenoic acid) is a melanin synthesis inhibitor. 10 (E)-Pentadecenoic acid inhibits nuclear translocation and reduces the protein level of phosphorylated microphthalmia-associated transcription factor (MITF), as well as decreases intracellular tyrosinase activity. 10 (E)-Pentadecenoic acid can be used in the research of skin pigmentation disorders.
    10(E)-Pentadecenoic acid
  • HY-121758
    2-Hydroxyicosanoic acid 16742-48-6 98.0%
    2-Hydroxyicosanoic acid (2-Hydroxy arachidic acid) is an ester product.
    2-Hydroxyicosanoic acid
  • HY-122029
    BRD6897 618395-82-7
    BRD6897 is a mitochondrial content inducer. BRD6897 does not alter the percent of cytoplasmic area occupied by mitochondria, but instead, induces a striking increase in the electron density of existing mitochondria.
    BRD6897
  • HY-122111
    (±)7-HDHA 90780-55-5 99.2%
    (±)7-HDHA ((±)7-HDoHE) is an ester product.
    (±)7-HDHA
  • HY-122373
    Coprine 58919-61-2 98%
    Coprine is an orally active disulfiram (HY-B0240)-like component and an inhibitor of aldehyde dehydrogenase. Coprine is isolated from Coprinus atranentarius. Coprine inhibits low Km aldehyde dehydrogenase in rat liver and increases blood acetaldehyde levels during in vivo ethanol metabolism. Coprine does not inhibit semi-purified low Km aldehyde dehydrogenase from rat liver in vitro. Coprine can be used in studies related to alcoholism.
    Coprine
  • HY-123115
    Leucrose 7158-70-5 98.53%
    Leucrose (5-O-α-D-Glucopyranosyl-D-fructose) is an orally active Sucrose (HY-B1779) isomer naturally found in pollen and honey. Leucrose promotes phosphorylation of JAK1 and STAT6, reduces pro-inflammatory mediators and cytokinesas (TNFα, and IL-1β), increases M2 macrophage polarization and suppresses DSS (HY-116282C)-induced colitis. Leucrose suppresses hepatic triglyceride accumulation, improves fasting blood glucose levels, and regulates hepatic lipogenesis and fatty acid β-oxidation in high-fat diet-induced obese mice. Leucrose is slowly hydrolyzed into glucose and fructose by α-glucosidase and acts as as a sugar substitute in diet.
    Leucrose
Cat. No. Product Name / Synonyms Application Reactivity